Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

Biological AI Model Jonathan Stelzer and Amos Tanay propose building biological AI around living system processes. On July 28, Stelzer and Tanay published an article in Cell on "biological language models". The authors suggest training AI on repetitive processes of an organism and combining molecules, cells, space, and time in one model. Many models already find patterns in DNA sequences, protein structures, and cell images, answering specific questions such as cell type, protein appearance, and risk associated with a set of features. However, experimenters often need to track the chain of events that led a cell to its state and choose an intervention in that chain. The authors propose taking a canonical biological process - a repeating sequence of events in a living system - as the basis for models. In such a model, molecular changes, cell states, and tissue context should be combined into one sequence, rather than a set of independent measurements with a final label. The authors call this system a "model of the world" for biology, which should link data to mechanism, showing how molecular and cell states change in space and time. The connection can be tested experimentally by changing the experimental condition and comparing the result with the model's prediction. This idea develops the "virtual cell" program, where researchers have tried to represent and simulate molecules, cells, and tissues in different states. The new article proposes organizing these data around a process with its own dynamics, where the developer should determine which process the system explains, which measurements relate to its different moments, and what intervention will test the proposed connection. Aging changes also pass through molecules, cells, and tissues over the years, and biological age assessment reduces the sample state to a single indicator. The process model asks a different question: what change in the cell leads to a change in tissue, and at what step can the experiment change the further course of the process. 🔗 Read original →