Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

Biological Age Test Ирина Конбой and Мэтт Кэберлайн discussed what a biological age test should show on July 29. Конбой suggests measuring disruptions in gene regulation, while Кэберлайн wants to check if the test result is repeatable and predicts health. Epigenetic clocks use DNA methylation and calculate age based on the pattern of these chemical marks. Конбой proposes using the same data to measure the spread of methylation in DNA regions where the average level of methylation remains constant with age. For the same blood samples, eight epigenetic clocks differed by an average of 17 years. Конбой wants to identify specific disruptions in gene regulation in the same data, which she links to the loss of regulation. Her approach involves measuring the spread of methylation values between people, which increases with age. This spread is what Конбой calls epigenetic noise. Her group described this approach in a 2023 article, where they selected CpG sites with consistent methylation levels and summarized the spread of values. Кэберлайн wants this signal to become a testable metric, which would require checking if the result is repeatable in parallel samples and if it predicts future organ function, disease risk, or treatment response. 🔗 Read original →