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Blockade Reduces Inflammation The blockade of the citrate carrier weakened the inflammatory secretions of aging cells in old mice. On July 29, Nature published a study of the metabolic step that helps an aging cell activate inflammatory genes. After three months of CTPI2 treatment, old mice showed reduced signs of inflammation and improved healthspan - health and physical function metrics. Aging cells stop dividing after damage or strong stress, but remain in the tissue. Many such cells secrete SASP, an inflammatory mixture of cytokines, growth factors, and enzymes. This changes the environment around the cell and the functioning of neighboring cells; over time, this background supports inflammation in tissues. Mitochondrial DNA and RNA can enter the cytosol, the cell's inner fluid. The cell perceives them as a sign of infection and activates proteins that trigger inflammatory genes. For SASP to work, another step is needed: genes must become accessible for reading. In the article by the group of Élène Martinie, this step was traced from mitochondria to chromatin. The mitochondria produce citrate, and the SLC25A1 protein exports it to the cytosol. There, citrate is converted into acetyl-CoA. This molecule attaches to histones - proteins around which DNA is packed - and opens up DNA sections near SASP genes. The inflammatory signal gains access to these genes and triggers the release of molecules. 🔗 Read original →