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Fruit Fly Lifespan Extended Researchers found that enhancing the dADAR enzyme in intestinal stem cells of fruit flies prolonged their lifespan. On July 28, Science Signaling published an article about how the fruit fly intestine switches between recovering from injury and quiet tissue renewal. The authors enhanced dADAR in the intestinal stem cells of old flies, resulting in improved intestinal function and longer lifespan. The intestine constantly updates its inner layer, with stem cells rarely dividing in undamaged tissue, but rapidly replenishing lost cells after injury. In old flies, this rhythm is disrupted, causing cells to divide too frequently, leading to improper intestinal growth and reduced self-maintenance. The authors traced this breakdown to dADAR, an enzyme that edits RNA, a molecule for assembling proteins. In the intestinal stem cells of old flies, dADAR was found to be less active, leading to unedited RNA of the Pumilio protein, which in turn fails to restrain the production of MAPK signaling pathway components. The researchers discovered that enhancing dADAR in the stem cells of old flies alleviated age-related intestinal dysfunction and extended their lifespan, as reported in Science Signaling. 🔗 Read original →