Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

Cancer Spreads After Chemo Researchers found that cisplatin-treated ovarian cancer cells released fructose, which helped the cancer spread in mouse models. On July 30, authors of a study in Nature Aging traced this process in high-grade serous ovarian cancer cells and mice. The fructose from the medium where the cells lived after chemotherapy altered the metabolism of neighboring cancer cells and facilitated their separation. The cisplatin damages the DNA of cancer cells, and some of the cells stop dividing but remain alive and release molecules into the surrounding environment. This state is called senescence, and the set of released substances is called SASP, the senescent-associated secretory phenotype. In the Nature Aging article, researchers worked with high-grade serous ovarian cancer, a common aggressive subtype of this tumor. They collected the medium where senescent cells lived after cisplatin and added it to dividing cells of the same tumor. In cell clusters, cancer cells separated from each other more often. When this medium was introduced to mice three times a week, more tumor nodes appeared in the abdominal cavity. The authors searched for the active component among small molecules and found that added fructose itself caused cell separation. 🔗 Read original →