Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

KinoPlex Map Released The authors of KinoPlex published a map of sites in human proteins where kinases can attach a phosphate on July 29. The researchers connected predicted AlphaFold structures of nearly 20,000 proteins with motifs - short sequence segments that kinases recognize. This map selects positions where a suitable motif matches the available arrangement in the protein's three-dimensional form. A kinase attaches a phosphate to a protein and changes its function, and through such switches, the cell responds to nutrition, stress, and growth signals. When a researcher looks for a kinase target, they usually look at several amino acids near the supposed site, which together form a motif that fits this enzyme. The KinoPlex authors applied the map to 1.8 million serine, threonine, and tyrosine residues - amino acids to which phosphate is usually attached. The map marked about 567 thousand positions as accessible for phosphorylation, and matching with individual kinase motifs left about 250 thousand "kinase - position" pairs where both conditions match. The authors verified the predictions with deep phosphoproteomics of K562 cells, a method that massively measures protein segments with attached phosphate. In these measurements, KinoPlex candidates matched the actually observed phosphorylated positions, as reported in Nature Aging, July 2026. 🔗 Read original →