Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

Life Extended by 29% Researchers described an experiment with membrane particles from E. coli bacteria with the aroD gene removed in an article accepted for publication on August 10 in the journal npj Aging. The loss of this gene reduces the availability of a precursor to vitamin B9, also known as folate, in bacteria. The median lifespan of C. elegans worms increased from 17.6 to 22.8 days. The aroD gene was chosen for this experiment based on a 2012 study that linked its removal to a longer lifespan in C. elegans and the suppression of bacterial folate synthesis. In the new experiment, the authors tested whether this effect is transmitted by membrane particles isolated from the bacteria. To obtain the particles, cells of mutant E. coli and the control strain BW25113 were disrupted, filtered, and centrifuged at high speed. The addition of PABA, a precursor to folate, to the culture of mutant bacteria eliminated the effect of its particles. Particles from normal E. coli treated with sulfamethoxazole, which blocks folate synthesis, had a similar effect. Both experiments link the effect to bacterial folate synthesis. The authors then moved on to the contents of the particles, isolating a candidate small RNA called Novel27. 🔗 Read original →