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Aging Serum Weakens Muscle Researchers found that serum from older donors weakened human muscle tissue contractions in a lab model. On August 12, a study in npj Aging reported on three-dimensional muscle tissue grown from human cells. After 48 hours in a medium with combined serum from 65–71 year old donors, it contracted about one-third weaker than in a medium with serum from 17–29 year old donors. The authors also linked this effect to the activation of NF-κB and tested quercetin as an intervention. In sarcopenia, the age-related loss of muscle mass and strength, muscles weaken. Early experiments showed that serum and plasma from older people reduced the size of mouse muscle cells. The authors of the new study tested whether this effect is reproduced in cells taken from human muscle tissue and whether the tissue assembled from them loses its ability to contract. They grew three-dimensional tissue from myoblasts, muscle precursor cells, in plate cells with flexible micro-posts. An electric impulse makes the tissue contract, and the deflection of the posts shows the contraction force. After seven days of growth, the authors added 10% combined serum from young or old donors to the medium for 48 hours. In a flat cell culture, the serum from older donors reduced the area of muscle cells. In three-dimensional tissue, the contraction force was about 30% lower. 🔗 Read original →