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Independent Analysis The study reevaluated 16 variants of the ΦX174 bacteriophage genome, proposed by the Evo 2 model, and found that they were 97 percent identical to the natural ΦX174 genome. The authors of the study, published in IEEE Spectrum on August 12, assessed the genomes based on two criteria: how similar they were to natural phages and how effective the procedure was in finding viable variants. The Evo 2 model was trained on the genomes of related phages and then used to generate 302 candidate genomes, which were then tested in a laboratory. Of these, 17 could not be synthesized, and of the remaining 285, 16 were found to be infectious. The results showed that the procedure was effective in finding viable variants, but the authors noted that this was due to the entire process, not just the model itself. The study also compared the created phages to natural ones and found that a mixture of created phages was able to suppress a resistant E. coli strain, while a mixture of natural phages was not. The authors suggested that future genome systems should be evaluated based on two measurable characteristics: the distance of their sequences from natural variants and the effectiveness of the path from model to laboratory testing. 🔗 Read original →