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Primate mRNA Delivery Researchers compared six variants of lipid nanoparticles for mRNA delivery in primates using 30 microliters of serum on August 11 in Nature Biotechnology, describing the snapCodes method. This method allows for the comparison of six lipid nanoparticle variants in a single non-human primate using a 30 microliter serum sample. The composition of the lipid nanoparticle determines the entire delivery chain, from the mRNA reaching the cell from the blood to its release and the cell's ability to assemble the protein. The study builds upon previous research from the same team in 2025, where researchers introduced a mixture of 45 lipid nanoparticle variants to a primate. To read the barcodes, they had to dissect cells from the liver, spleen, bone marrow, and blood. The authors noted that comparing carriers in primates becomes a separate stage of development, with a high cost and potential harm to animals. The snapCodes method transfers the reading of the result to the serum, allowing for a more efficient comparison of variants. Each of the six carrier variants contained mRNA with instructions for a protein with a SNAP tag and its own DNA code snapCode. The authors first tested this chain in control experiments and then intravenously administered the six variants to mice and non-human primates. 🔗 Read original →