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Neurons Revitalized Researchers found that enhancing cellular cleanup in neurons derived from elderly donors' skin cells improved some mitochondrial metrics. On August 16, 2026, Eva Kliman and colleagues published a study on cortical neurons directly converted from skin cells of people of different ages. The neurons from elderly donors had weaker acidic stages of autophagy, a cellular cleanup process. The authors increased the formation of autophagosomes, vesicles for this cleanup, and some mitochondrial metrics in the neurons from elderly donors approached those of young cells. The study was published in Nature Aging, July 2026. The researchers used G2-115 to increase autophagosome formation, resulting in a 60% increase in their number in all age groups. The authors compared young and old cell lines, as well as six pairs of samples taken from the same men approximately 15 years apart. In the old cells, 16.64% of autophagosomes were acidic, compared to 47.06% in young cells. The results suggest that the lack of lysosomes in the neurites hinders autophagosome acidification, leading to more frequent mitochondrial division and fusion. 🔗 Read original →