Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

Aging Cell Type Обри де Грей questioned whether one gene shows if a cell retains its type during partial reprogramming. On August 17, Майкл Уэст referenced a graph of two genes during brief induction of Яманаки factors - proteins that change gene function. Обри де Грей responded that an early sign of a cell transitioning to an unspecialized state grows only slightly before TERT, a gene associated with telomerase. Their exchange raised a practical question: what changes indicate that a cell has altered its age markers but still retains its type. Яманаки factors (OSKM) lead cells to pluripotency when used long-term - a state from which different cell types can arise. With brief OSKM induction, researchers seek a regime in which age markers have shifted, but the cell retains specialization. In a post on August 17, Уэст wrote that brief OSKM expression may "reverse developmental processes, as in cloning". For clinical application, he terms this approach "induced tissue regeneration" and references a temporal graph from a 2018 study. The graph compares ZFP42 and TERT, with ZFP42 being an early sign of movement towards pluripotency. In a response post, де Грей noted the closeness of these lines: "ZFP42 growth precedes TERT growth by only a little". A short OSKM pulse must be evaluated on a temporal map of several cell programs: age markers, signs of its original type, early and late pluripotency markers, and TERT. 🔗 Read original →