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Early Menopause in Mice Researchers found that female mice born after a full IVF route had a reduced ovarian reserve. A study published in the Journal of Clinical Investigation on August 17 examined female mice born after undergoing hormonal stimulation, in vitro fertilization, embryo culture, and transfer to a recipient female. At 12 and 39 weeks, these mice had fewer follicles in their ovaries and lower estrogen levels compared to mice conceived naturally. These female mice also had fewer live births in four consecutive pregnancies. The ovary stores immature eggs in follicles, structures where the egg grows and receives support. The authors investigated whether the full IVF route affects the future function of the ovary. They found that the number of germ cells in the ovaries of both groups was the same at the end of fetal development. However, at 12 and 39 weeks, the authors counted fewer follicles in the IVF group, and their ovaries were smaller relative to body mass, with lower estrogen levels in the blood. The authors linked these measurements to a faster depletion of the follicular reserve after birth. Changes were also observed in subsequent pregnancies, with a higher frequency of resorbed embryos in the uterus and fewer live births in a series of four pregnancies. 🔗 Read original →