Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

Brain Atlas Study A recent study published in Cell on August 18 has created a detailed map of the brain of 23 female macaques, highlighting the white matter of the brain stem as particularly vulnerable to age-related changes. The researchers collected 2,955,873 cell nuclei and tracked how age-related shifts are distributed across different brain regions and cell types. The study found that the brain ages unevenly in different regions and cells, with the most consistent age-related shifts found in the pons and medulla - regions of the brain stem. The white matter in these regions consists of bundles of nerve fibers coated with myelin, a fatty substance that accelerates signal transmission. The researchers observed a decline in the activity of genes related to myelin and lipid synthesis in oligodendrocytes, the cells responsible for producing myelin. The study's findings also showed changes in the signals of cells that support nerve tissue or give rise to oligodendrocytes. The researchers confirmed a decrease in PDGFRA gene RNA in oligodendrocyte precursor cells, which codes for a receptor of growth signals. The study's data is available on the NHPABC portal, allowing researchers to search for age-related shifts by specific brain region, cell type, and programs related to myelin. 🔗 Read original →