Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

Brain Cell Aging Researchers studied how different brain cell types interact and transmit signs of aging. On August 15, a study was published in Aging Cell, where scientists transferred media from five human brain cell types to each other and measured which cells developed signs of aging. A 15-day experiment showed that astrocytes and microglia more often triggered such responses in other cells. The study focused on cellular aging, or senescence, a state where a cell stops dividing and changes its function after stress. It releases a set of proteins and molecules, known as SASP, into the surrounding environment, which can alter the state of neighboring cells. The authors worked with five human immortalized cell lines, including astrocytes, vascular lining cells, microglia, oligodendrocytes, and neuron-like cells. The cell cultures were treated with BrdU for seven days to induce signs of aging. Then, the media from each cell type was transferred to other cells. The media from treated astrocytes and microglia increased the proportion of cells with SA-β-gal, a senescence marker, in astrocytes and vascular lining cells. Microglia responded to media from several other cell types, and the authors further checked other senescence markers, such as DNA damage and mitochondrial function. 🔗 Read original →