Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

Aging Skin Study Researchers found that in the aging epidermis of mice, the proteins BMAL1 and YAP together activate inflammatory genes. A recent study published in Nature Aging, August 2026 investigated the outer layer of mouse skin, tracing how BMAL1, a biological clock protein, and YAP, a protein responding to tissue mechanical properties, alter the function of inflammation genes. The epidermal cells of old mice receive two changing signals: one from the tissue beneath them and another from immune cells. The basement membrane, a thin layer between the epidermis and the deeper dermis, resists deformation more strongly, while the dermis accumulates cells releasing IL-17, a molecule signaling inflammation. The authors compared adult and old epidermis at six points in the daily cycle, finding that among 118 inflammatory genes more active in old skin, only four changed rhythmically. This suggests that BMAL1 is involved in a sustained age-related reorganization of gene function, not just daily fluctuations. 🔗 Read original →