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Bone Repair Falters After repeated injury in mice, less new bone formed, although the bone marrow appeared recovered. In an article published on August 19 in Nature Communications, scientists investigated whether bone marrow cells could re-engage in bone repair after a previous injury. After a second injury, their descendants less often became osteoblasts, and less new bone formed. The bone marrow's stromal cells support the environment within the bone marrow. After injury, some of these cells can become osteoblasts - cells that build bone. To track this change, the authors genetically labeled cells in mice and compared one and two operations that triggered bone marrow repair. After the second operation, micro-CT scans showed that less new trabecular bone formed. The labeled cells less often transformed into osteoblasts, and their descendants more often became adipocytes of the bone marrow. In a separate model of repeated fractures, the same pattern emerged: less new bone and osteoblasts, more adipocyte descendants. Initially, the interval between operations was about four weeks. By the next injury, the bone marrow under the microscope already appeared comparable to the undamaged one. 🔗 Read original →