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New Theory of Aging
Researchers Michael Levin and co-authors proposed a third theory of aging, where cells lose their common goal to maintain tissue shape. On August 18, Leo Pió-López, Navnit Javanda, and Michael Levin published a preprint review of aging theories. The authors group these theories by their presumed primary cause: accumulation of damage, late consequences of evolutionary programs, and loss of coordinated cell purpose in tissue.
The authors' own theoretical model describes how cells maintain the overall structure of tissue. By "purpose," the authors mean the work of feedback: cells compare the current state of tissue with its target structure and reduce the discrepancy. During development, this process creates the body's form. According to the authors' model, after development is complete, cells may maintain their local functions but poorly coordinate repair, growth, and cell replacement with the organ's form.
One possible carrier of such coordination, the authors consider, is bioelectric patterns - the distribution of electrical potentials in tissue. The review also mentions chemical signals and mechanical properties of tissue. If cells poorly maintain or read the common scheme of signals, the tissue, according to the authors' hypothesis, deviates from the necessary structure and function, as seen in Nature Aging, July 2026.
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