Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

Palbociclib Reduces Inflammation The drug palbociclib weakened inflammation in aging cells and improved physical performance in old mice. Cyclin D1 typically helps a cell begin division, but the authors found its accumulation in cells that had already stopped dividing. In their model, cyclin D1, along with CDK6, maintained DNA damage and activated inflammatory genes. On August 20, the journal Nature Aging published an article on the unexpected role of cyclin D1 in senescent cells. Senescence is a stable state after stress, such as DNA damage, where a cell stops dividing, remains in tissue, and can release signaling molecules that support inflammation. In July, abemaciclib was also found to weaken the inflammatory secretions of senescent cells in old mice. The authors of the new study investigated a different pathway - the role of cyclin D1 and CDK6 in cells that had already stopped dividing. They found that reducing cyclin D1 or CDK6 levels weakened the activity of inflammatory and interferon genes, while intervening in CDK4 had little effect. The researchers then checked the mechanism, finding that the CCND1-CDK6 complex supported DNA damage. 🔗 Read original →