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Lung Repair Boosted A new study on August 19 found that an antibody can strengthen a weakened signal between lung cells in older mice, replenishing their supply of repair cells for air sacs. The authors linked the decline of AT2 cells, which participate in the repair of alveoli, to weaker chemical signals from neighboring fibroblasts. The antibody activated the Fzd5 receptor on AT2 cells, increasing their supply. After damage, AT2 cells divide and then some of them transform into AT1 cells, forming a thin surface for gas exchange. A 2018 study on mice helped identify Wnt2 as a key signal supporting the supply of dividing cells. The new study found that this local support weakens with age in older mice, with fewer AT2 cells and lower Wnt2 production from neighboring fibroblasts. The authors then attempted to replenish the reserve directly in AT2 cells using an antibody that activates Fzd5. The treatment increased the number of AT2 cells in older mice to levels similar to those in young animals over eight weeks. 🔗 Read original →