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CoQ10 Trial in Elderly The University Medical Centre Ljubljana has registered a 10-week trial of coenzyme Q10 in people over 65 with early signs of frailty. One hundred participants will receive either 200mg of coenzyme Q10 or a placebo daily for ten weeks. The primary outcome measure will be GDF-15, a protein that indicates cellular and mitochondrial stress. The study will also include people with low physical function test results or high vulnerability scores. Coenzyme Q10 plays a role in the functioning of mitochondria, the cellular structures where nutrients are converted into energy. Researchers will check one chain at several levels: CoQ10 concentration in plasma will show if the supplement reached the bloodstream; GDF-15 will provide a measurable signal of cellular stress; physical tests, grip strength, and frailty scales will allow comparison of this signal with how a person walks, gets up from a chair, and preserves strength. The trial is scheduled to start in September 2026 and end in February 2027, as listed in the ClinicalTrials.gov registry. 🔗 Read original →