Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

Longer Life in Worms Researchers from McGill University published a study on August 20 in eLife examining nine long-lived lines of the roundworm Caenorhabditis elegans. All of these lines lived longer than normal worms, but in two groups, some of the same genes worked in opposite directions. The authors then tested some of these genes in animal experiments. The study found that mutations that extend life are usually studied one line at a time and under different conditions, which can reflect both biology and experimental design. The authors first confirmed that all nine lines indeed lived longer than normal worms, and then compared them in a single design. For each line, they took at least six independent samples, and for control worms, 18 samples. The authors measured gene function using RNA-seq, a method that counts RNA and shows how actively a cell uses each gene. The profiles were divided into three groups, with 507 genes showing increased activity in four lines, and 188 of the same genes showing decreased activity in two lines. A similar divergence was found in genes regulated by the DAF-16/FOXO protein, which turns other genes on and off. 🔗 Read original →