Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

We need to translate Russian news post into natural English, format per rules. First line: short headline under 90 chars, no markdown, no '#'. Then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines. Wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks . At most 4-5 per post, never a whole sentence. Wrap study/journal citations and publication references in single underscores (e.g. Nature Aging, July 2026). We need to preserve all facts, numbers, names, citations exactly. Let's identify facts: - Review introduced "arrhythmic zone" – temperature interval where internal clocks lose autonomous rhythm, but cell/organism still viable. - Review published August 24 in The FEBS Journal. - Authors compiled data from bacteria to mammals, propose separating temperature at which clocks lose autonomous rhythm from lower temperature limit of viability. - Circadian clocks – intracellular mechanisms setting ~daily rhythm. - In some temperature range, rhythm remains close to daily, though individual biochemical reactions go faster or slower. This property is temperature compensation. - Review asks what happens below this boundary when rhythm no longer sustains itself, but cell/organism still viable. - "We call 'arrhythmic zone' the interval in which viability is preserved while autonomous rhythm weakens or disappears." - This is well seen in experiment with cyanobacterial proteins. - In 2017 experiment, three purified proteins KaiA, KaiB, KaiC mixed in test tube: mechanism that creates daily oscillations. - Upon cooling to 19°C, rhythmic changes in KaiC became weaker and smoothly went to zero, while cycle length almost unchanged. - This transition is called Hopf bifurcation: amplitude of autonomous oscillations decays, period almost preserved. - Protein system still responded to environmental temperature cycles; strongest entrainment by cycle close to its own 24‑h rhythm. - In arrhythmic zone, external repeating signal can still drive rhythm of mechanism that lost autonomous drive. - Review also mentions more complex systems. - In thin slices of mouse suprachiasmatic nucleus (SCN) – brain area that sets rhythm for whole body – at 15°C rhythmic calcium changes and gene expression stopped; after rewarming they resumed. - In culture of human U2OS cells, viability remained high at 25–37°C, while around 30°C the rhythm of luminescence of genetic reporter BMAL1-dLuc, which tracks clock work, disappeared. - In six participants, hair follicle cells retained similar amplitude of clock gene activity after a day at 18 and 28°C; authors linked this to blood flow smoothing temperature of living tissue. - In cell culture temperature is set by medium; in living tissue it is smoothed by blood flow. - Now for each organism we can seek three different temperatures: lower viability limit, limit of autonomous rhythm, limit of rhythm still supported by external daily signal. - Especially interesting are psychrophiles – organisms that grow best at 15°C and below. - In polar cyanobacteria already found kaiABC genes linked to bacterial clocks. - Authors propose to measure their autonomous rhythm at native temperature and compare three thresholds in cold‑adapted organisms. We need to wrap key numbers, percentages, drug/company/gene names, dates in double asterisks. At most 4-5 per post. Select maybe: August 24, The FEBS Journal, 19 °C, 15 °C, 25–37 °C, 30 °C, 18 °C, 28 °C, kaiABC. That's many; need limit to 4-5. Choose most important: date, journal, key temperatures (maybe 19°C, 15°C, 30°C), gene name kaiABC. That's 5. We can wrap each in double asterisks.… 🔗 Read original →