Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

We need to translate Russian news post into natural English, format per rules. First line: short headline under 90 chars, no markdown, no '#'. Then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines. Wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks . At most 4-5 per post, never a whole sentence. Wrap study/journal citations and publication references in single underscores (e.g. Nature Aging, July 2026). We have a preprint on bioRxiv dated August 24 (presumably 2024? Not given year). The text: "24 августа авторы выложили на bioRxiv препринт об электрической стимуляции коры у 14 бодрствующих мышей." So date: August 24 (year unspecified). We'll keep as "August 24". Wrap date in double asterisks? It's a key date. Could be one of the important facts. Also numbers: 14 mice, 2,725 neurons, 53 brain areas, frequencies 8, 28, 140 Hz, 10 series of 10 seconds each, 5 µA current, 300 ms, percentages: 16%, <1%, 21–25 percentage points, 77%, 30%, <10%, 15%, 0%. Also mention Neuropixels probes. We need to select at most 4-5 double asterisk facts. Choose maybe: 14 mice, 2,725 neurons, 8 Hz, 28 Hz, 140 Hz, 16%, 21–25 percentage points. That's 5. Ensure not whole sentence. We need to wrap study/journal citations in single underscores. There's a bioRxiv preprint. So we can put bioRxiv, August 24 (or bioRxiv preprint, August 24). Use single underscores. We must not add commentary. Just translation. Now produce headline: maybe "Cortical stimulation frequency dictates neural response scale and mechanism in mice". Count characters: Let's count: "Cortical stimulation frequency dictates neural response scale and mechanism in mice". That's about 78 characters. Good. Now blank line. Then body paragraphs. We need to split into short paragraphs 2-3 sentences each. Let's craft paragraphs: Paragraph 1: Introduce experiment: 14 awake mice, two Neuropixels probes recorded 2,725 neurons across 53 areas. Authors posted preprint on bioRxiv August 24 about electrical cortical stimulation. Paragraph 2: Describe stimulation: sinusoidal current at 8, 28, or 140 Hz, ten 10‑second blocks each, 5 µA amplitude. During rest and running, they measured spike timing relative to wave phase. Paragraph 3: Effects: at 8 Hz neurons synchronized spikes to a specific wave phase with little change in mean firing rate; at 140 Hz near the electrode some cells shifted firing rate briefly. The frequency determined which combination of responses was observed. Paragraph 4: Modeling: synchrony strength predicted by electric field magnitude at 8 Hz and by local anatomical connectivity at 140 Hz; adding connectivity data improved the model by 21–25 percentage points. Authors link this to a shift from direct field effects to synaptic spread. Paragraph 5: Local high‑frequency response: 5 µA bursts increased firing in putative inhibitory cells to 16% at 140 Hz (vs <1% at 8 Hz) within first 300 ms, while excitatory‑like cells decreased firing, interpreted as brief local inhibition. Paragraph 6: Influence of running: running altered distributed synchrony in 77% of areas at 8 Hz, 30% at 28 Hz, and <10% at 140 Hz; local frequency shift depended on running in 15% of areas at 8 and 28 Hz and 0% at 140 Hz. Paragraph 7: Conclusion: frequency sets mechanism and scale of response, brain state especially modulates distributed synchrony; authors propose using frequency to select desired response type and accounting for state when measuring synchrony. Now we need to wrap important facts in double asterisks. We have selected: 14 mice, 2,725 neurons, 8 Hz, 28 Hz, 140 Hz, 16%, 21–25 percentage points. Also maybe 5 µA, 300 ms, but we limited to 4-5. We'll stick to those five.… 🔗 Read original →