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Magnetite nanodiscs trigger astrocyte‑specific calcium response in mouse hippocampus On 19 August the authors posted a preprint describing an experiment in which mice received magnetite nanodiscs coated with an antibody that binds the astrocyte surface protein GLAST, injected into the dentate gyrus of the hippocampus. Applying alternating magnetic fields of 25–28–50 mT produced a statistically larger intracellular calcium response in astrocytes than hematite particles of the same shape; the calcium signal was monitored by fiber photometry of a genetically encoded calcium‑sensitive reporter. Between the second and fifth week after a single injection, magnetite discs elicited a stronger astrocyte response than the hematite control, whereas mice expressing the reporter in neurons showed no difference between the two materials. The method builds on earlier work from 2022 that used antibody‑functionalized magnetic particles moved by strong field gradients and a 2025 open coil for weak alternating fields developed by Po‑Han Chang’s group; three Science studies have linked astrocyte calcium signals to neural network state switching, allowing causal tests. 🔗 Read original →