Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

We need to translate Russian news post into English, format per rules. First line: short headline under 90 chars, no markdown, no '#'. Then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines. Wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks . At most 4-5 per post, never a whole sentence. Wrap study/journal citations and publication references in single underscores (e.g. Nature Aging, July 2026). We need to preserve all facts, numbers, names, citations exactly. Let's extract facts: - Date: 27 August (article in Frontiers in Aging). So date: August 27 (maybe year not given). We'll keep "August 27". Could be 2024? Not given. We'll just keep "August 27". - Researchers compared female lab strain C57BL/6 with added naked mole-rat nmrHas2 gene and control group. - By 12 months, hearing deteriorated in all animals, and ABR thresholds (minimum loudness sound to which auditory system still responds) did not statistically differ between groups. - nmrHas2 encodes enzyme that produces hyaluronan — long extracellular matrix molecule. In naked mole-rat this hyaluronan is especially large. - In 2023 work, mice with same gene had median lifespan increased by 4.4%, maximum lifespan increased by 12.2%; authors also observed less age-related inflammation. - New experiment tested whether such intervention preserves a separate age-related function. - Authors chose C57BL/6 because age-related hearing loss appears relatively early in this strain. - At one month, the added gene was induced with tamoxifen, and at three and twelve months hearing measured via ABR. ABR records electrical response of auditory nerve and brainstem to clicks and sounds of various frequencies. Threshold shows quietest sound to which system still responds. - Main comparison involved eight transgenic and nine control twelve-month-old females. - For clicks and sounds of six frequencies — from 4 to 32 kHz — no differences in hearing thresholds were found. - In cochlea, part of inner ear, transgenic mice had nmrHas2 RNA: the added gene was being read in this tissue. - Experiment separately checked whether genetic construct works in ear tissue and whether hearing is preserved. - Authors propose two hypotheses. Variant of gene Cdh23 characteristic for C57BL/6 is linked to early age-related hearing loss and could have weakened intervention effect. They also suppose that in cochlea there may have accumulated little especially large hyaluronan. - Comparison with mouse line where hearing deteriorates for other reason, or with noise- and drug-induced damage models, could distinguish these explanations. We need to wrap key numbers, percentages, gene names, dates in double . At most 4-5 per post. Let's decide which to highlight: - nmrHas2 (gene name) - Cdh23 (gene name) - 4.4% (median lifespan increase) - 12.2% (maximum lifespan increase) - August 27 (date) - maybe 12 months (age) - maybe 8 transgenic and 9 control (sample size) but that's maybe too many. We need at most 4-5 double asterisk wrapped items. Let's pick: gene names (nmrHas2, Cdh23) maybe count as two; percentages (4.4%, 12.2%) two more; date August 27 one more; that's 5. Could also include "12 months" but we already have 5. Let's keep 5. We need to ensure we don't wrap whole sentences. So we wrap just the token inside double asterisks.… 🔗 Read original →