Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

We need to translate Russian news post into natural English, format with headline line (<90 chars), blank line, then body paragraphs (2-3 sentences each) separated by blank lines. Wrap few genuinely important facts (key numbers, percentages, drug/company/gene names, dates) in double asterisks. At most 4-5 per post. Wrap study/journal citations and publication references in single underscores. We need to preserve all facts, numbers, names, citations exactly. No added commentary. No source link. We need to identify important facts: Outer Bio presented Yuna on August 24 (date). Yuna system for four-week experiments on living human skin experiments. 8-millimeter full-thickness biopsy. 3D-printed porous insert. Study 2020 other model preserved integrity up to nine days. Authors observed biopsies from 19 donors up to four weeks and performed 118 replicates. Early adaptation period; gene activity profiles weeks 1-4 closer to each other than fresh skin. Next experiment: biopsies of four donors treated three weeks with immune signaling molecules IL-17A and IL-22. Inflammatory changes persisted: gene activity related to inflammation and skin barrier changed; inflammatory proteins secreted into medium. Tofacitinib, a drug that blocks one immune signaling pathway, attenuated part of these changes. Separate experiment: skin of three donors aged 58–74 treated three weeks with dasatinib alone or combined with quercetin. At end, authors registered reduced levels of IL-6 and MMP1. Calculated by SenSkin gene activity — a marker of skin cellular aging — and authors' chronic inflammation signature also decreased. Four-week window allows separating early tissue adaptation from changes caused by long treatment. In it one can observe processes in human skin that unfold over weeks, not only first days of culture. We need to wrap key numbers, percentages, drug/company/gene names, dates in double asterisks. At most 4-5 per post. So we need to select maybe 4-5 important facts: date August 24, 8‑millimeter biopsy, 19 donors, 118 replicates, four‑week window, maybe IL-17A/IL-22, tofacitinib, dasatinib+quercetin, SenSkin, etc. But we must limit to 4-5 double asterisks total. So we need to be selective: maybe highlight date, 8‑mm biopsy, 19 donors, 118 replicates, four‑week window. Or maybe include drug names as important facts? The instruction: "Wrap the few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks. Be selective: at most 4-5 per post, never a whole sentence." So we can include drug names as important facts. But we need to limit total double asterisk occurrences to 4-5. Let's decide to include: August 24, 8‑millimeter, 19 donors, 118 replicates, four‑week. That's 5. Good. We must not double asterisk other numbers like 58–74 years, IL-6, MMP1, etc. So we will leave those plain. Now citations: we have a 2020 study (other model). We need to wrap study/journal citations and publication references in single underscores. The text mentions "В исследовании 2020 года другая модель человеческих кожных эксплантатов сохраняла целостность ткани до девяти дней в описанных авторами условиях." No journal name given. So we can just put 2020 study? But we need to preserve citation exactly; we don't have a journal name. Could use 2020 study as placeholder. However instruction: "Wrap study/journal citations and publication references in single underscores (e.g. Nature Aging, July 2026)." So we need to wrap whatever citation appears. Since there is no explicit journal, we can wrap the phrase "2020 study" in underscores. Or maybe "В исследовании 2020 года" -> we can wrap "2020 study". Let's do 2020 study.… 🔗 Read original →