Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

Intestinal ACP7 secretion extends lifespan in C. elegans Researchers artificially boosted ACP7 production in the intestine of C. elegans and found that lifespan increased only when the enzyme was secreted from gut cells. The median lifespan rose by 10%, and the age at which 10 % of worms survived increased by 22%; the study appeared on 27 August in Cell Reports. Using TurboID labeling in the endoplasmic reticulum, the team performed mass spectrometry on worms aged 3, 8, and 13 days, identifying 238 extracellular or secreted proteins, of which 191 changed with age and 89 have human homologs. Four candidate proteins were tagged with fluorescent markers and all were detected outside the intestine and in coelomocytes; ACP7 levels were shown to rise with the worms’ age. Removing the 21‑amino‑acid signal peptide kept ACP7 inside the intestine and abolished its life‑extending effect, while the ACP7‑7A variant with seven substitutions in the metal‑binding domain retained secretion but lost phosphatase activity and failed to prolong lifespan. Human ACP7 was secreted in cell culture and demonstrated phosphatase activity on an artificial substrate; a computational screen pointed to 28 extracellular proteins that could be dephosphorylated by worm ACP7, providing targets for future work linking the enzyme’s activity to longevity. 🔗 Read original →