Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

We need to translate Russian news post into English, format per rules. First line: short headline under 90 chars, no markdown, no '#'. Then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines. Wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks . At most 4-5 per post, never a whole sentence. Wrap study/journal citations and publication references in single underscores _ (e.g., Nature Aging, July 2026). We need to preserve all facts, numbers, names, citations exactly. Let's extract facts: - Date: 28 августа (August 28) in Cell Reports (re-analysis of data). So date: August 28 (year not given? The article presumably 2024? Not given. We'll keep "August 28" as given. - Data: single-cell brain data of male mice. - After QC: 12,310 cells remained. - Pairs of young and old mice with surgically joined circulations – heterochronic parabiosis. - One-cell atlas of such pairs in 2022 collected by Robert Palovich with coauthors; Palovich also in current team. - Mice of same age served as control. - Authors identified eight microglial states. - In six activated states, 75 genes changed similarly in at least five of them. - Forty of these 75 genes entered the common age shift in all four brain regions. - Common program manifested in all regions, but each had its own shifts. - In young mice with old partners, gene activity in cerebellum and cortex changed in same direction as normal aging, albeit weaker. - Under both influences, most changes seen in cerebellum. - In old mice with young partners, in cerebellum 41 genes changed activity opposite to age changes; in cortex and hippocampus 25 each; in striatum three. We need to wrap key numbers, percentages, drug/company/gene names, dates in . At most 4-5 per post. Select maybe: 12,310 cells, August 28, 75 genes, 40 genes, 41 genes, 25 genes, three genes? That's many. Need max 4-5. Choose most important: total cells, date, number of genes commonly shifted (40), number of opposite changes in cerebellum (41), maybe number of opposite changes in cortex/hippocampus (25). That's 5. We must not wrap whole sentences. So embed within sentences. Citations: we have Cell Reports (journal) and the 2022 one-cell atlas by Robert Palovich et al. We need to wrap study/journal citations and publication references in single underscores _. So we should put Cell Reports and maybe 2022 one-cell atlas? The instruction: wrap study/journal citations and publication references in single underscores (e.g., Nature Aging, July 2026). So we should put the journal name in underscores. Also maybe the 2022 atlas reference? Could be considered a publication reference; we can put Robert Palovich et al., 2022 or similar. But we need to preserve exact names. The Russian text: "Одно-клеточный атлас таких пар в 2022 году собрал Роберт Палович с соавторами ; Палович вошёл и в нынешнюю команду." So we can cite as Robert Palovich et al., 2022 (or 2022 one-cell atlas by Robert Palovich et al.). We'll put the citation in underscores. We need to ensure we don't add extra commentary. Now format: Headline line, blank line, then paragraphs. Paragraphs 2-3 sentences each. Let's craft: Headline: "Heterochronic parabiosis reshapes microglial gene activity across mouse brain regions" Check length: count characters: "Heterochronic parabiosis reshapes microglial gene activity across mouse brain regions" Let's count: H(1) ... I'll approximate less than 90. It's fine. Blank line. Paragraph 1: maybe 2-3 sentences about study date, data, QC.… 🔗 Read original →