Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

Jaba Tkemaladze proposes centriole inheritance as a marker of aging in renewing tissues On 28 August he posted a preprint on the Research Square platform outlining the “centriole counter” hypothesis. In tissues that renew through repeated divisions, a cell lineage can retain changes in the centriole from one division to the next. In his earlier framework of four hallmarks of cellular age, Tkemaladze placed centrioles alongside telomeres and mitochondria. The current preprint narrows the focus to tissues that constantly replenish themselves with new cells. A renewing tissue simultaneously replaces specialized cells and maintains a reserve of cells that can divide again. During division, the two daughter cells may receive 🔗 Read original →