Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

We need to translate Russian text into English, format: first line headline under 90 chars, no markdown, no '#'. Then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines. Wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks . At most 4-5 per post, never a whole sentence. Wrap study/journal citations and publication references in single underscores _ (e.g., Nature Chemical Biology, August 26, 2024? Actually date given: 26 августа в Nature Chemical Biology вышла работа о BrainCAB — метке на основе бринзоламида. So citation: Nature Chemical Biology, August 26, 2024? The year not given but likely 2024? The original Russian says "26 августа в Nature Chemical Biology вышла работа". No year given; we can just put Nature Chemical Biology, August 26 (no year). But we need to preserve facts exactly: date is 26 августа. We'll translate to August 26. No year given, so we omit year. We need to wrap key numbers etc: e.g., BrainCAB tag based on brinzolamide, one chemical step, concentration ~8 times higher, 20 mg/kg dose, Car4 gene, etc. Must be selective: at most 4-5 double asterisk wrapped facts. Choose: BrainCAB tag based on brinzolamide, one chemical step, concentration ~8-fold higher, 20 mg/kg dose, Car4 gene knockout. That's 5. Wrap study/journal citation in single underscores: Nature Chemical Biology, August 26. Now produce headline under 90 chars: maybe "BrainCAB Tag Enables Antibody Delivery Across Blood‑Brain Barrier in Mice and Newborn Macaques". Count characters: Let's count: "BrainCAB Tag Enables Antibody Delivery Across Blood‑Brain Barrier in Mice and Newborn Macaques". Count: B(1) r2 a3 i4 n5 C6 A7 B8 (space9) T10 a11 g12 (space13) E14 n15 a16 b17 l18 e19 s20 (space21) A22 n23 t24 i25 b26 o27 d28 y29 (space30) D31 e32 l33 i34 v35 e36 r37 y38 (space39) A40 c41 r42 o43 s44 s45 (space46) B47 l48 o49 o50 d‑51 B52 r53 a54 i55 n56 (space57) B58 a59 r60 r61 i62 e63 r64 (space65) i66 n67 (space68) M69 i70 c71 e72 s73 (space74) a75 n76 d77 (space78) N79 e80 w81 b82 o83 r84 n85 (space86) M87 a88 c89 a90 q91 u92 e93 s94. That's 94 characters, exceeds 90. Need under 90. Let's shorten: maybe "BrainCAB Tag Delivers Antibodies Across Blood‑Brain Barrier in Mice and Macaques". Count: "BrainCAB Tag Delivers Antibodies Across Blood‑Brain Barrier in Mice and Macaques". Let's count: B1 r2 a3 i4 n5 C6 A7 B8 (space9) T10 a11 g12 (space13) D14 e15 l16 i17 v18 e19 r20 s21 (space22) A23 n24 t25 i26 b27 o28 d29 i30 e31 s32 (space33) A34 c35 r36 o37 s38 s39 (space40) B41 l42 o43 o44 d‑45 B46 r47 a48 i49 n50 (space51) B52 a53 r54 r55 i56 e57 r58 (space59) i60 n61 (space62) M63 i64 c65 e66 s67 (space68) a69 n70 d71 (space72) M73 a74 c75 a76 q77 u78 e79 s80. That's 80 characters. Good. Now body: need short paragraphs 2-3 sentences each, separated by blank lines. We need to include double asterisks for key facts: BrainCAB tag based on brinzolamide, one chemical step, concentration ~8-fold higher, 20 mg/kg dose, Car4 gene knockout. We need to wrap study/journal citation in single underscores: Nature Chemical Biology, August 26. We must preserve facts: mention that tag attaches via one chemical step to protein or short RNA/DNA; binds CA-IV on brain vasculature; antibody with tag accumulates in brain ~8-fold higher after 7 days in mice; in Car4 knockout mice no enrichment; in newborn macaques 20 mg/kg IV dose, antibody with tag found in brain regions and intercapillary tissue on days 5 and 7; each condition had one animal; nanobodies and siRNA also bind CA-IV and enter cells in cell assays; animal experiments focused on antibody. Now format: after headline, blank line, then paragraphs. Paragraph 1: introduce BrainCAB tag, its basis, one-step attachment, target CA-IV. Paragraph 2: describe BBB, need for antibody to cross, concept grew from 2023 work, AAV uses CA-IV.… 🔗 Read original →