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Light‑softening gel lets researchers control crypt division in mouse intestinal organoids On 29 August, researchers published a study in Advanced Science describing how a light‑softening hydrogel enabled precise control of crypt division in mouse intestinal organoids. The organoids are three‑dimensional models of the intestinal epithelium that contain stem‑cell‑rich crypts. In normal growth or repair, a crypt can split into two daughter crypts, but in standard organoids this splitting occurs randomly, making it hard to follow a single structure from start to finish. They placed the organoids in a soft gel that a laser can locally soften. First, the laser created a single channel for one crypt; after three days, two V‑shaped channels were made at its base. The tissue grew into the softened regions, allowing the researchers to set the time and place of division and to watch one crypt develop into two 🔗 Read original →