Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

We need to translate Russian news post into natural fluent English, format per rules. First line: short headline under 90 chars, no markdown, no '#'. Then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines. We need to wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks . At most 4-5 per post, never a whole sentence. Wrap study/journal citations and publication references in single underscores _ (e.g., Nature Aging, July 2026). We must preserve all facts, numbers, names, citations exactly. No added commentary. We need to identify citations: The article published August 25 (year? Not given, but likely 2024? Actually they mention "В статье, опубликованной 25 августа". No year given. Could be 2024? But we must preserve exactly as given: "25 августа". No year. So we keep that date. Also mention "В работе 2025 года липиды оказались..." So we have year 2025. Also mention "В статье, опубликованной 25 августа". Could be 2024? But we just keep "25 августа". No year. We need to wrap key numbers, percentages, drug names, etc. Let's identify important facts: - Blood only partially reflected metabolism of five organs in mice receiving life-extending interventions. - Plasma compared with liver, kidneys, gastrocnemius muscle, and two adipose tissues in genetically heterogeneous UM-HET3 mice. - From four to twelve months animals received caloric restriction or one of four drugs: rapamycin, canagliflozin, 17-alpha-estradiol, acarbose; these regimens previously extended mouse lifespan. - Similarity between plasma and tissues varied with organ, regimen, sex. - Blood can be taken repeatedly from live animal, so its composition used to infer organ metabolism. - Plasma mixes substances from food, organs, gut microbes. - Determining what happened in one organ from such analysis requires direct verification. - In human studies, NAD+ level in whole blood changed after nicotinamide riboside, but hardly responded to age, exercise, nutrition. - Authors of new article checked which tissue changes in life-extending regimens are simultaneously visible in blood. - In 2025 work, lipids were the most noticeably changing class of substances in six sample types. - New article clarifies which of these shifts can be linked to specific tissue via plasma. - Each tissue had 33–37% of annotated metabolites also found in plasma. - Metabolites are small molecules participating in metabolism. - Set of common molecules for each tissue was its own, so plasma composed of partial overlaps with several organs. - After statistical check filtering random differences, authors highlighted 260 compounds that changed both in plasma and at least one tissue under one regimen. - Ergothioneine, a food compound, changed in same direction in blood, muscle, liver, kidney, subcutaneous fat under several regimens. - Lipids with docosahexaenoic acid (DHA) — omega-3 fatty acid — changed concordantly in blood and two adipose tissues. - Another candidate, 1,5-anhydroglucitol, changed in same direction in blood, liver, kidney under regimens with strong lifespan extension. - In males authors found more groups of related molecules with concordant response than in females. - For this mouse model a useful blood marker requires linking to specific tissue, regimen, and sex. - Repeated blood analyses become more informative when such linkage is first established by organ measurements.… 🔗 Read original →