Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

We need to translate Russian news about macrophage CD38 NAD+ depletion in placenta of aged mice, humans, pigs. Need to produce headline under 90 chars, then blank line, then body paragraphs 2-3 sentences each, separated by blank lines. Must wrap key numbers, percentages, drug/company/gene names, dates in double asterisks. At most 4-5 per post. Must wrap study/journal citations and publication references in single underscores (e.g., Nature Aging, July 2026). Here citation: article published August 27 in Nature Communications. So we need Nature Communications, August 27? Actually format: Nature Communications, August 27 (year? Not given). We'll include year maybe 2024? Not given. We'll just put Nature Communications, August 27. We need to select up to 4-5 double-asterisk facts. Important facts: NAD+ levels lower in older women (35-44 vs 20-25). Percentages: stromal cells decreased from 44.8% to 23.9%; macrophages increased from 7.7% to 17.1%. CD38 upregulation. Fetal weight increased from 0.887 to 0.961 gram. IUGR decreased from 24.4% to 8.9%. Also maybe mention eight-month-old mice. Also mention nicotinamide riboside and inhibitor 78c. But we must limit to 4-5. Choose: NAD+ levels lower in older women (maybe not a number but statement). Better to include numbers: stromal cells 44.8%→23.9%; macrophages 7.7%→17.1%; fetal weight 0.887→0.961 g; IUGR 24.4%→8.9%; CD38 upregulation (maybe not a number). That's 4 numeric facts. Could also include eight-month-old mice but that's less critical. We'll stick to those four. We need to wrap each in double asterisks. Eg 44.8%, 23.9%, etc. Also percentages and numbers. We must not wrap whole sentences, just the facts. We need to ensure we don't exceed 4-5 double asterisks. We'll have maybe 5: stromal % decrease, macrophage % increase, fetal weight increase, IUGR decrease, NAD+ levels lower (maybe we can avoid). Let's pick 4. We'll wrap: 44.8%, 23.9%, 7.7%, 17.1%, 0.887 g, 0.961 g, 24.4%, 8.9% – that's many. Need to be selective: maybe combine each pair as a range? But rule says wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks. At most 4-5 per post, never a whole sentence. So we need to limit total number of double-asterisk wrapped items to 4-5. Could wrap each fact as a phrase, e.g., stromal cells dropped from 44.8% to 23.9% counts as one wrapped fact (though contains two numbers). That's okay. Similarly macrophage fraction rose from 7.7% to 17.1%. Fetal weight increased from 0.887 g to 0.961 g. IUGR fell from 24.4% to 8.9%. That's four wrapped facts. Good. We also need to wrap study/journal citation in single underscores: Nature Communications, August 27. Now produce headline under 90 chars: maybe "Macrophage CD38 Depletes NAD⁺ in Aged Placenta, Impairing Fetal Growth". Count characters: Let's count: "Macrophage CD38 Depletes NAD⁺ in Aged Placenta, Impairing Fetal Growth". Count: M(1) ... Let's approximate: It's likely under 90. We'll ensure. Now body: split into short paragraphs 2-3 sentences each, separated by blank lines. We need to preserve all facts, numbers, names, citations exactly. No extra commentary. Let's craft paragraphs: Paragraph 1: Introduce study: article published Aug 27 in Nature Communications; macrophages deplete NAD+ via CD38 in placenta of old mice, humans, pigs; NAD+ lower in older women. Paragraph 2: Describe cellular changes: stromal cells decreased from 44.8% to 23.9%; macrophages increased from 7.7% to 17.1%; closer proximity in old placenta. Paragraph 3: Mechanism: CD38 on macrophages breaks down NMN, blocking NAD+ production in stromal cells; antibody blockade restores NMN effect.… 🔗 Read original →