Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

We need to translate Russian news post into natural English, format with headline under 90 chars, blank line, then short paragraphs (2-3 sentences each). Wrap few genuinely important facts (key numbers, percentages, drug/company/gene names, dates) in double asterisks, at most 4-5 per post. Wrap study/journal citations and publication references in single underscores. We need to identify facts: date: 26 августа (August 26) in JACS Au. Also mention AF3-ReD method. Possibly mention beta-subunit of F1-ATPase, proteins OxlT and NarK. Also mention that reducing number of sequences in MSA also finds closed variants but some predictions diverge. Also mention that authors suggest using intermediate variants as starting points for MD. We need to select at most 4-5 double-asterisk facts. Likely: date August 26, journal JACS Au, protein β-subunit of F1-ATPase, proteins OxlT and NarK maybe count as two but could be considered one fact? Better to keep under 5. Let's pick: August 26, JACS Au, β-subunit of F1-ATPase, OxlT, NarK (that's 5). Or we could combine OxlT and NarK as one fact: "transporter proteins OxlT and NarK". That would be one fact. Then we have 4 facts: date, journal, β-subunit, transporter proteins. Good. Now citations: we need to wrap study/journal citations and publication references in single underscores. The article is in JACS Au on August 26. So we can put JACS Au, August 26 maybe. Or JACS Au and date separate? The rule: wrap study/journal citations and publication references in single underscores. So we can put JACS Au, August 26 as a single underscored phrase. Now formatting: headline under 90 chars, no markdown. Then blank line, then body paragraphs separated by blank lines. Each paragraph 2-3 sentences. Let's craft headline: "AF3-ReD expands AlphaFold3 to capture multiple protein conformations". Count characters: let's count: "AF3-ReD expands AlphaFold3 to capture multiple protein conformations". That's 61 characters approx. Good. Now body. Paragraph 1: Introduce method and date/citation. Something like: "On August 26, researchers published a study in JACS Au describing AF3-ReD, a modification of AlphaFold3 that steers the model toward alternative protein structures. The approach leaves the neural‑network weights unchanged but adds a repulsive term that pushes subsequent runs away from conformations already found." That's 2-3 sentences. Paragraph 2: Explain why multiple conformations matter, give examples: β-subunit of F1-ATPase switching between open and closed states upon ATP binding, and transporter proteins OxlT and NarK that alternate between inward‑ and outward‑open states. Wrap key facts in double asterisks: August 26, JACS Au, β-subunit of F1-ATPase, OxlT and NarK. Ensure each fact is wrapped. Paragraph 3: Show results: standard AlphaFold3 gave only the open state for the β‑subunit even with ATP, whereas AF3-ReD produced open, closed and intermediate models that match experimental structures. Also note that reducing the MSA depth yielded some closed models but many predictions diverged from known structures. Paragraph 4: Conclude with authors' suggestion: using the intermediate conformations as starting points for molecular dynamics simulations can help map ligand‑induced transitions, making structure prediction the first step in dissecting protein functional cycles. We need to ensure double asterisks only around selected facts, not whole sentences. Let's embed them. Important: At most 4-5 double asterisk facts. We'll have four: August 26, JACS Au, β-subunit of F1-ATPase, OxlT and NarK. Good. Now ensure we don't accidentally double asterisk other numbers like "multiple" etc. Avoid.… 🔗 Read original →