Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

We need to translate Russian news post into English, format per rules. First line: short headline under 90 chars, no markdown, no '#'. Then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines. Wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks . At most 4-5 per post, never a whole sentence. Wrap study/journal citations and publication references in single underscores. We need to preserve facts, numbers, names, citations exactly. Let's extract facts: - In Cell Reports, article published August 31 (31 августа) in Cell Reports about combined experiments with yeast, worms, flies, short-lived fish, mice. - Authors automated counting of survivors to compare action of substances in different organisms and conditions. - Mouse experiment with a substance that extends life in lab models, when started late, lasts from one to one and a half years. - To choose next such experiment, need comparable results from fast models. - In different studies dose, feed, genetic line, observation method vary; thus same candidate may get different evaluations. - Authors built compatible systems for five models. - In yeast, miniature viability test accounts for medium acidity: it itself can change cell survival. - Chambers at set intervals photograph worms and flies, program recognizes death by sustained immobility. - In killifish, short-lived fish, authors standardized drug pellets. - In mice, interventions start at late age and together with lifespan they observe animal activity. - Full comparison of 423 substances authors performed in three fast models: yeast, worms, flies. - Of them 130 extended life in at least one species, 32 in two, and metformin, rifampicin, and furazolidone — in all three. - In experiments with canagliflozin, drug extended lifespan in male mice but not females; with late start females lived less, and subsequent work linked this to about 20 times higher concentration of substance in blood. - Next check here concerns dose, sex, diet, and mode of delivery. - Five compatible systems help choose next long mouse experiment: they show whether result holds when changing species and conditions, and where it depends on dose, sex, diet, or mode of delivery. We need to wrap key numbers, percentages, drug/company/gene names, dates in double asterisks. At most 4-5 per post. We need to decide which facts to highlight: maybe date (August 31), number of substances (423), numbers 130, 32, three drugs (metformin, rifampicin, furazolidone), maybe 20 times higher concentration. That's 5 items: date, 423, 130, 32, 20 times. Or we could include drug names as important facts. But drug names also need to be highlighted? The rule says wrap key numbers, percentages, drug/company/gene names, dates. So drug names also should be wrapped. But we have limited to 4-5 double asterisks total. We need to be selective. We could choose: date (August 31), number of substances (423), numbers (130, 32), and maybe the 20‑fold higher concentration. That's 5 double asterisks. Drug names we could leave without asterisks, but they are drug names; maybe we can include one drug name as double asterisk instead of a number? But we need at most 4-5, we could do 4: date, 423, 130, 20‑fold. Or we could do date, 423, metformin, rifampicin, furazolidone (that's 5). But we need to include numbers too. Let's think: The most important facts: date, total substances tested, number that extended life in at least one model, number that extended in two models, the three drugs that worked in all three, and the 20-fold concentration difference. That's many.… 🔗 Read original →