Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

We need to translate Russian text into English, format as per rules. First line: short headline under 90 chars, no markdown, no '#'. Then blank line, then body split into short paragraphs (2-3 sentences each), separated by blank lines. Wrap few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks . At most 4-5 per post, never a whole sentence. Wrap study/journal citations and publication references in single underscores (e.g. Nature Aging, July 2026). We need to preserve all facts, numbers, names, citations exactly. Let's extract facts: - Experience on human cells and mice: turning off ALDH3B2 shifted duct cells to β-like state. - September 2 (date) in journal Science Translational Medicine article about how turning off one gene changed part of cells lining pancreatic ducts. - After transplantation of these cells into diabetic mice, glucose level was lower than in animals with control cells. - β-cells of pancreas secrete insulin — hormone regulating blood sugar level. - In diabetes these cells are lacking or insufficient, so their function is attempted to be replenished by donor islets and cells grown from stem cells. - Authors looked for another source: duct cells that pancreas uses to secrete digestive juice. - To find gene that keeps these cells in original state, researchers performed whole-genome CRISPR screening: they turned off different genes one by one and selected cells where insulin gene activity started. - For mass search they used PANC-1 duct cell line, which can be grown in large quantity. - Among eight candidates ALDH3B2 gave in this line the highest insulin gene activity and lowest KRT19 gene, a marker of duct cells. - Then ALDH3B2 was turned off in purified primary human duct cells. - In them activity of β-cell genes increased, insulin granules appeared, and raising glucose caused secretion of human insulin. - In two groups of five diabetic mice each, altered or control cells were transplanted under kidney's outer capsule; in animals with altered cells glucose was lower. - On day 56 after removal of transplant it returned to control group level, and after glucose injection human insulin was detected in blood. - Single-cell analysis, where gene activity measured in each cell separately, showed scale of transition: insulin gene worked in 18.1% of cells with ALDH3B2 knocked out and 0.6% of controls. - About 93% of cells in both groups remained active KRT19 — marker of duct identity. - Resulted mixed β-like population: part of cells combined duct cell and β-cell markers. - ALDH3B2 became genetic target for further research on how cells of the organ itself can be directed to replenish lost function. Now we need to format. First line: short headline under 90 chars. Something like: "Turning off ALDH3B2 reprograms pancreatic duct cells toward insulin‑producing β‑like state". Count characters: Let's count: "Turning off ALDH3B2 reprograms pancreatic duct cells toward insulin‑producing β‑like state". Count: T(1) ... Let's approximate: It's likely under 90. We'll ensure. Now blank line. Then paragraphs: each 2-3 sentences. We need to wrap key numbers, percentages, gene names, dates in double asterisks. At most 4-5 per post. Important facts: date September 2, journal Science Translational Medicine, gene ALDH3B2, gene KRT19, PANC-1 line, percentages 18.1% and 0.6%, about 93%, day 56, groups of five mice each. We need to be selective: maybe choose date, journal, gene ALDH3B2, percentages 18.1% and 0.6%, day 56. That's 5 items. Wrap each in .… 🔗 Read original →