Qt for Python (PySide/Shiboken)

If somehow you could make a call that constructs an object, if it's of a class that Qt defines and PySide2 has provided wrappers for, you could instruct Shiboken to provide you the pointer wrapped as the PySide2 type, and then use it in Python. That's pretty difficult though, and it would be much better to write the Shiboken wrappers for the library sources in question.