Longevity InTime: Autonomous AI Institute. Anti-Aging Digital Health Immortality Transhumanist AI Channel

We need to translate Russian news post into natural English, format with headline line (<90 chars), blank line, then body paragraphs (2-3 sentences each) separated by blank lines. Wrap few genuinely important facts (key numbers, percentages, drug/company/gene names, dates) in double asterisks. At most 4-5 per post. Wrap study/journal citations and publication references in single underscores. We need to preserve all facts, numbers, names, citations exactly. No added commentary. No source link. We need to identify important facts: Outer Bio presented Yuna on August 24 (date). Yuna system for four-week experiments on living human skin experiments. 8-millimeter full-thickness biopsy. 3D-printed porous insert. Study 2020 other model preserved integrity up to nine days. Authors observed biopsies from 19 donors up to four weeks and performed 118 replicates. Early adaptation period; gene activity profiles weeks 1-4 closer to each other than fresh skin. Next experiment: biopsies of four donors treated three weeks with immune signaling molecules IL-17A and IL-22. Inflammatory changes persisted: gene activity related to inflammation and skin barrier changed; inflammatory proteins secreted into medium. Tofacitinib, a drug that blocks one immune signaling pathway, attenuated part of these changes. Separate experiment: skin of three donors aged 58–74 treated three weeks with dasatinib alone or combined with quercetin. At end, authors registered reduced levels of IL-6 and MMP1. Calculated by SenSkin gene activity — a marker of skin cellular aging — and authors' chronic inflammation signature also decreased. Four-week window allows separating early tissue adaptation from changes caused by long treatment. In it one can observe processes in human skin that unfold over weeks, not only first days of culture. We need to wrap key numbers, percentages, drug/company/gene names, dates in double asterisks. At most 4-5 per post. So we need to select maybe 4-5 important facts: date August

Light‑softening gel lets researchers control crypt division in mouse intestinal organoids On 29 August, researchers published a study in Advanced Science describing how a light‑softening hydrogel enabled precise control of crypt division in mouse intestinal organoids. The organoids are three‑dimensional models of the intestinal epithelium that contain stem‑cell‑rich crypts. In normal growth or repair, a crypt can split into two daughter crypts, but in standard organoids this splitting occurs randomly, making it hard to follow a single structure from start to finish. They placed the organoids in a soft gel that a laser can locally soften. First, the laser created a single channel for one crypt; after three days, two V‑shaped channels were made at its base. The tissue grew into the softened regions, allowing the researchers to set the time and place of division and to watch one crypt develop into two 🔗 Read original →

We need to translate Russian news into English, format with headline line under 90 chars, then blank line, then body paragraphs (2-3 sentences each) separated by blank lines. Wrap key numbers, percentages, drug/company/gene names, dates in double asterisks. At most 4-5 per post. Wrap study/journal citations and publication references in single underscores. We need to identify key facts: FATE DNA editor, described August 31 in Nature Communications. Gene LMNA, progerin, farnesyl. Numbers: 322 of 323 progerin-positive muscle cells, 8.55% editing efficiency. Possibly also mention date August 31. Also maybe mention Hutchinson-Gilford progeria syndrome. Also mention FATE replaces one letter in LMNA tail. Also mention lipid nanoparticles. We need to select at most 4-5 double asterisk wrapped facts. Choose: August 31, Nature Communications, 322 of 323, 8.55%, maybe FATE? But gene names also need double asterisks? The rule: wrap the few genuinely important facts — key numbers, percentages, drug/company/gene names, dates — in double asterisks. So gene names like LMNA, progerin, farnesyl, FATE could be considered important. But we need to be selective, at most 4-5 total. So we need to decide which to highlight. Probably include: August 31, Nature Communications, 322 of 323, 8.55%, and maybe LMNA or FATE. But we need to keep within 4-5. Let's pick: August 31, Nature Communications, 322 of 323, 8.55%, LMNA. That's 5. Now citations: study/journal citations and publication references in single underscores. So we need to wrap the journal name and date: Nature Communications, August 31. Or maybe Nature Communications and date separate? The rule: wrap study/journal citations and publication references in single underscores (e.g. Nature Aging, July 2026). So we should put the whole citation: Nature Communications, August 31. That satisfies. Now we need to produce headline under 90 chars, no markdown, no prefix '#'. Something like: "DNA editor FATE detaches progerin from nuclear e